Endocrine Abstracts

Glucocorticoid-induced osteoporosis is the most common form of secondary osteoporosis. The primary effects are on osteoblasts and osteocytes. Glucocorticoids impair the replication, differentiation and function of osteoblasts. These effects lead to a suppression of bone formation, characteristically in the pathogenesis of this form of osteoporosis. On the other hand, available software for image analysis are expensive, inflexible or methodologically dense. ImageJ, an open sour...

Introduction: Severe hypoglycemia and retinopathy are two of the main complications of diabetes mellitus (DM). Traditionally, glycosylated hemoglobin (or A1C) has been used as the gold standard measurement of glycemic control; however, there is a significant percentage of complications riskassociated with the evolution of diabetes that is not fully explained by this single marker. Short and long-term glycemic variability has been postulated as one of the main variables that co...

Objective: To study the association between the state of iodine nutrition, and the risk of total and cause mortality in a representative sample of the Spanish adult population.Design: Longitudinal observational study to estimate mortality risk according to urinary iodine (UI) concentrations using a sample of 4370 subjects >18 years representative of the Spanish adult population participating in the national study [email protected] (2008–2010). We used ...

Background: Although obesity and has been associated with COVID-19 mortality, the absolute and relative risks for Type 2 diabetes (DM2) is unknown. The aim of this study was to analyse metabolic characteristics of patients infected by COVID-19 hospitalised and evaluate whether DM2 have an impact in this group of patients.Methods: We retrospectively analysed data of COVID-19 patients hospitalized to a large academic hospital system in Zaragoza between Mar...

Introduction: One of the often-discussed topics in the management guidelines for Type 1 Diabetes Mellitus (T1DM) is the ideal time gap that should exist between patient check-ups. A period of three to six months is usually recommended, which sometimes is difficult to achieve due to the high number of patients. But to what extent does the time gap between appointments in the follow-up of T1DM patients affect their diabetes’ control?Objectives: To kn...

Introduction: Hypertriglyceridemia induced pancreatitis (HIP) is an uncommon condition accounting for 1–4% of cases of acute pancreatitis, mostly associated with poor glycemic control in diabetic patients. Diabetic ketoacidosis (DKA) may complicate the clinical course of HIP; however, few studies have documented this association. Our objective was to identify clinical and demographic differences between HIP patients with co-existing DKA compared to those without DKA.<...

The reprogramming effects of an excess of testosterone during pregnancy in males born to PCOS mothers as well as in animal models for PCOS has been only recently evaluated. We have found in a sheep model of PCOS that prenatal T (PT) excess impact on the testis of adults with increased Sertoli cell (SC) number, decreased sperm count, and reduced germ cell (GC) number. The ontogeny of such disruptions and the mechanisms have not been established. This study addressed the impact ...

Introduction: Generously supported by IPSEN)-->Acromegaly is a rare and insidious disease associated with an increased morbidity and mortality. Trans-sphenoidal (TNS) surgery remains the primary therapeutic option, in particular for intrasellar microadenomas and noninvasive macroadenomas. Aims of this study were to describe diagnostic features and to verify the impact of TNS surgery on treatment of acromegaly over three decades, befo...

Background: Familial isolated pituitary adenomas (FIPA) is a rare inherited disorder accounting for about 2% of pituitary adenomas. Mutations in the Aryl hydrocarbon receptor Interacting Protein (AIP) gene have been described in about 15% of FIPA families and rarely in early onset sporadic pituitary adenomas. Among the AIP mutations reported so far, the R304X represents, after the Finnish founder mutation Q14X, the second most common one.Me...

The recombinant human interferon α-2a (rhIFN α-2a) is a cytokine with antiviral, antiproliferative and immunomodulatory properties, indicated for the treatment of hepatitis B and C and leukemias. The rhIFN α-2a consists of a 165–166 amino acids with molecular mass of 19.5 kDa. The aim of this work was to develop and validate the reversed-phase (RP-LC) and size-exclusion (SE-LC) liquid chromatography methods for the physico-chemical characterization of rhIFN...